AVOID DRUG IBUPROFEN & ACE INHIBITORS DURING COVID 19 (CORONA VIRUS INFECTION)


Author:


Dr. Uma Kumar
Professor & Head
Department of Rheumatology
AIIMS, New Delhi


'AVOID DRUG IBUPROFEN & ACE INHIBITORS DURING COVID 19 (CORONA VIRUS INFECTION)'

Preliminary findings: One of the factors besides associated  co-morbidities (diabetes, hypertension, strike, coronary artery disease)   for more severe COVID 19 in Italy was that most patients took ibuprofen at home. Ibuprofen accelerates the multiplication of the virus. 

Those interested in details can read following article-

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/fulltext 
"Human pathogenic coronaviruses (severe acute respiratory syndrome coronavirus [SARS-CoV] and SARS-CoV-2) bind  to their target cells through angiotensin-converting enzyme 2 (ACE2), which is expressed by epithelial cells of the lung, intestine, kidney, and blood vessels.4 The expression of ACE2 is substantially increased in patients with type 1 or type 2 diabetes,  who are treated with ACE inhibitors and angiotensin II type-I receptor blockers (ARBs) .4 Hypertension is also treated with ACE inhibitors and ARBs, which results in an upregulation of ACE2.5 ACE2 can also be increased by thiazolidinediones and ibuprofen.  suggest that ACE2 expression is increased in diabetes and treatment with ACE inhibitors and ARBs increases ACE2 expression. Consequently, the increased expression of ACE2 would facilitate infection with COVID-19. We therefore hypothesise that diabetes and hypertension treatment with ACE2-stimulating drugs increases the risk of developing severe and fatal COVID-19. "

Maintain hand hygiene, respiratory hygiene and social distancing to keep the virus away from your loved ones


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